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Due to heterogeneity across studies, statistical analysis could not be conducted. AEs in women and children were abdominal pain, asthenia, constipation, dizziness, dry mouth, drowsiness, dyspepsia, headache, incontinence, nasal congestion, nausea, orthostatic hypotension, and somnolence. Patients discontinued tamsulosin primarily because of adverse events (AEs) or insufficient response. The studies (n %) evaluated healthy subjects (18 11%) or patients with lower urinary tract symptoms/BPH (90 56%), ureteral stones/renal colic (42 26%), prostatitis (4 3%), or other conditions (6 4%). Of these, four studies included women only and three included children.

Overall, 160 articles involving 46,072 participants met the inclusion criteria.

A study was included if patients were randomized to receive treatment with any dose of tamsulosin capsules, tablets, or an oral controlled absorption system and numerical safety results were reported. Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015). In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. Safety of Tamsulosin: A Systematic Review of Randomized Trials with a Focus on Women and Children.Īlthough tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. Treatment satisfaction was greater with tadalafil vs placebo, with no significant difference between tamsulosin and placebo. Men with recent prior Î±-blocker therapy reported greater treatment satisfaction with tadalafil vs placebo, with only borderline difference for men without prior therapy. â€¢ Across treatment groups, the incidence of clinical progression was highest in men with a baseline IPSS of 8 mm as a separate subgroup to find the effect of the used drugs on the relatively large stones, we detected that the expulsion rate of these stones was significantly higher in the patients who received the combined treatment in comparison with any of the other three groups (P 65 years), history of erectile dysfunction (yes/no), LUTS/BPH severity (IPSStreatment-subgroup interactions.

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Patients in the EPVL plus tamsulosin group achieved similar stone-free rates compared with the other two groups, but the speed of the stone expulsion was quicker for both sexes and all age groups (about a week pâ€‰ 42.0 mL, in all subgroups of baseline PSA level, and all other baseline subgroups (P â‰¤ 0.001). Compared with the two control groups, these rates were significantly higher (EPVL group was 0% and 50.5% and medical expulsive therapy group was 0% and 50.0%, pâ€‰â€‰0.05).

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In the EPVL plus tamsulosin group, 60.1% of patients showed detectable fragment expulsion at 48 hours, and 91.1% were stone free at 7 days.

Stone diameters ranged from 0.32 to 1â€‰cm. There were no significant differences in general characteristics between the three groups. Between July 2013 and July 2014, 672 patients diagnosed with DUC were randomly divided into three groups a group receiving EPVL plus 0.4â€‰mg oral tamsulosin daily (PO qd) (experimental group, nâ€‰=â€‰236), a group receiving 0.4â€‰mg tamsulosin PO qd (nâ€‰=â€‰222), and a group receiving EPVL only (nâ€‰=â€‰214) (control groups). The aim of this study was to evaluate a new technology, extracorporeal physical vibrational lithecbole (EPVL) combined with tamsulosin, as a treatment for distal ureteral calculi (DUC). The obstruction of the urinary tract by calculi at the narrowest anatomical areas leads to impaired drainage and severe pain. Liu, Guanlin Cheng, Yue Wu, Weijie Jia, Xiaolong Hu, Jiasheng Xie, Guohai Chen, Xueqin Treatment of Distal Ureteral Calculi Using Extracorporeal Physical Vibrational Lithecbole Combined with Tamsulosin: A New Option to Speed Up Obstruction Relief.